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Best Stop Smoking Medication 
Zyban (Bupropion ) is a medication that works by interfering with the chemicals in the brain that causes addiction. You start taking bupropion for 1-2 weeks before you plan to stop smoking.
If you want to stop smoking, taking bupropion ( Zyban) Bupropion roughly doubles your chance of success. For many smokers, Bupropion ( Zyban) is the best stop smoking medication available, since no more nicotine is being consumed.
Bupropion ( Zyban) is a drug first developed to treat depression. It was found that it helped smokers quit smoking. It is not clear how the medication works. It alters the level of some chemicals in the brain (neurotransmitters). This seems to relieve the withdrawal symptoms that you get when you stop smoking (such as craving, anxiety, restlessness, headaches, irritability, hunger, difficulty with concentration, or just feeling awful).
About twice the number of smokers who take Bupropion stop smoking compared to those who don't. Up to 1 in 5 smokers who really want to stop will do it with the help of bupropion. >> Study
Bupropion does not 'make' you stop smoking. You still need determination to succeed, and to break the smoking habit. A combination of Bupropion with counselling from a nurse, doctor, pharmacist, or other health professional increases your chance of successfully stopping smoking.
Most people take Bupropion without any problem. Read the packet leaflet for a full list of possible side-effects and cautions.The most common are:
- a dry mouth
- sleep disturbance
- drowsiness
- seizures
- high blood pressure
Blood pressure sometimes goes up in people who take Bupropion. This is more common in people who take Bupropion plus nicotine replacement therapy at the same time (nicotine gum, etc). You should have a baseline blood pressure reading done before you start treatment and it should be monitored from time to time. It should be checked weekly if you take Bupropion plus nicotine replacement therapy.
You should not take bupropion if you:
Bupropion should be used with caution if you have heart disease. However, if you have heart disease, the benefits of stopping smoking usually outweigh other concerns. Also, the dose may need to be reduced if you have some medical conditions, or if you take certain medicines. Tell your doctor or pharmacist if you:
Whilst you are taking Bupropion, tell your doctor or pharmacist if you are prescribed or buy any new medication. Also, tell a doctor or pharmacist if you are taking any of the following medications.
Articles
Bupropion May Be Effective for Smoking Cessation in Primary Care SettingsNews Author: Laurie Barclay, MD
September 14, 2007 — Bupropion may be effective in the primary care setting and more than doubled the odds of continuous abstinence from smoking, according to the results of a double-blind, placebo-controlled, randomized trial reported in the September 10 issue of the Archives of Internal Medicine.
"Studies undertaken in academic settings have shown that bupropion hydrochloride can double the odds of smoking cessation compared with placebo," write Roldano Fossati, MD, from the Università degli Studi di Milano in Milan, Italy, and colleagues from the General Practice Tobacco Cessation Investigators Group. "To assess whether these results are applicable in primary care, we launched a double-blind, placebo-controlled, randomized trial to be conducted by general practitioners."
From April 2004 to May 2005, 71 Italian general practitioners enrolled 593 healthy smokers in this study, of whom 400 were randomized to receive bupropion hydrochloride, 150 mg twice a day, and 193 were randomized to receive placebo daily for 7 weeks. During the 1-year study, participants had 4 clinical visits and 3 telephone calls, in addition to the baseline visit. The main outcome measures were biochemically confirmed continuous abstinence at week 7 and at week 52.
From week 4 to week 7, 41.0% of the subjects in the bupropion group were continuously abstinent, as were 22.3% of those in the placebo group (multivariate odds ratio [OR], 2.37; 95% confidence interval [CI], 1.60 - 3.53). From week 4 to week 52, the rates of continuous abstinence were 25% in the bupropion group and 14% in the placebo group (OR, 2.11; 95% CI, 1.32 - 3.39).
Mean weight gain was similar in both groups. For long-term abstainers, weight gain was 3 kg in women and 4 kg in men. Although more participants in the bupropion group vs the placebo group had an adverse event, the percentage discontinuing use of the study medication was similar in both groups.
"Bupropion more than doubled the odds of continuous abstinence from smoking," the study authors write. "The adherence of general practitioners and participants to the protocol was excellent, making our findings robust and easy to generalize to the context of primary care."
Limitations of the study include less frequent follow-up visits vs that reported in other studies, which could lead to an underestimation of adverse events; nonmedical factors such as the clinician-patient relationship might have influenced the selection of the study population and compliance; and the concern that 3 telephone calls and 5 visits in a year might be an excessive burden for most primary care clinics.
"The adherence of GPs [general practitioners] and participants to the research protocol was excellent," the investigators conclude. "Bupropion was efficacious, with an absolute 25% of participants continuously abstinent at 1 year; it doubled the odds of continuous abstinence from week 4 to week 7 and from week 4 to week 52 compared with placebo and was also well tolerated. This study, conducted in the general practice setting, does not simply replicate previous studies undertaken in academic centers but also provides reliable data that physicians may use to make their best evidence-based decisions in the difficult task of helping people quit smoking."
Arch Intern Med. 2007;167:1791-1797.
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